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Our people need you NOW more than ever.
Preface by John de Nugent
…..Recent donations
Think about this as you hang on to your money…. This is an actual screenshot from the Klaus Schwab video of June 2020 at the World Economic Forum/Davos, Switzerland. If these pedo billionaires win, and they are using Covid to try to do it, then this will literally become true. All your assets (home, car, furniture, everything) will be legally taken, retitled, as belonging to the government to pay off all personal, corporate and government “debts” — and then you will have a cash chip embedded in your body to get your monthy allowance. But the State can just switch off the money chip if you rebel.
I wrote a comrade and donor today:
I regret, dearest comrade, that I cannot answer, or at least answer quickly, every comment, even if it has the most useful content. You know that the clock is now ticking toward “President Kamala Harris.”…. The senile Biden will be replaced by this energetic witch, and then we will see the NWO move forward very fast toward our genocide — unless I stop it.
Margi with huevos rancheros, made from scratch, also thanks our donors!
— 8 March 2021 $250 loan forgiven by P in Florida
— 8 March 2021 $310 and ltr re Gematria from F in Georgia
…..The article — is the Covid vaxx destroying lungs?
In part one of this series we discussed how since the first roll-out of COVID-19 vaccines hit the open market, the untested vaccine has wreaked havoc on people globally, resulting in death and widespread injury at a rate NOT seen with ANY other vaccine in history.
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In fact, thus far in the United States alone, the vaccine in its various forms has killed between 500-600 people a week, with that rate increasing further in recent days.
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The evidence coming out of the Vaccine Adverse Event Reporting System (VAERS) – a national early warning system to detect possible safety problems in U.S. licensed vaccines – has been shocking, to say the least.
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Yes, the COVID-19 vaccine is THAT dangerous.
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VAERS is a federally funded “United States program for vaccine safety”, co-managed by the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA).
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And again, no Evil Russians in sight…..
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VAERS data sets for “COVID-19 Vaccine Injuries” can be found, downloaded. and searched for at
www.vaers.hhs.gov/data/datasets.html
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The website’s even got the “.gov” bit in it. No amount of phony SNOPES “fact checking” can debunk that 😉
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And here’s what I ascertained – as stated in part 1 of this piece – from only half an hour of research on the site….
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As of February 4, 2021, the COVID-19 vaccine DIRECTLY resulted in 563 deaths and 12,697 injuries. As of February 18, VAERS reported that a total of 1095 deaths and 19,907 injuries occurred as a result of the “application of the COVID-19 vaccine”.
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Now, compare these results to VAERS reports issued for ALL other vaccines.
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Bottom line: there have been LOADS of deaths attributed to the COVID jab, but next to NONE associated with dozens and dozens of other potent vaccines.
This might be an unpopular opinion, but I am not even remotely averse to the administration of vaccines.
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My kids (from two relationships) are both vaccinated and have never had an issue apart from the standard site reaction (wher the needle went in) and a mild immune and inflammatory response.
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I was vaccinated against a variety of illnesses when I was at school, then again more recently against Tetanus, when I had a nasty run-in with a garbage bag with an exceedingly sharp, dirt-covered tin lid protruding from it!
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I’ve never had more than an arm ache and a bit of a fever as a result of a vaccination and have NEVER contracted Measles, Smallpox, Rubella, Tetanus, or Japanese Encephalitis.
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I’m joking about my reason for travelling to Asia. 😉 I was there to check out Sikhism, visit some people I’d met on my travels, eat some curry, and explore a few beaches during a semester I took off.
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The experience I have had with vaccines over the years is similar to the experience most others typically have with vaccines.
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Most people – as I did – read the box, check with their doc if they’re allergic or have issues with any of the vaccines adjuvants (or the foundation of the vaccine which can be egg-based etc).
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They are then inoculated with the dead or attenuated (meaning live & active but weakened) viral antigen, deal with a slight fever and systemic discomfort, and go about their business, while their body mounts an immune response that confers them long-lasting protection against whatever infection the vaccine was designed to protect them against.
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One in hundreds of thousands (literally) might face short-term autoimmune issues like Immune Thrombocytopenia, known as ITP. An autoimmune disease is a medical condition where one’s own immune system mistakenly attacks the body it’s tasked with protecting. The immune system normally protects the body against bacteria, germs and viruses.However, when someone is afflicted with an autoimmune disease, their body for all intents and purposes, attacks itself.
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Vaccine-induced ITP can cause red and purple bruises, as well as tiny subcutaneous reddish dots (that look like a rash but have more in common with a hickey, or what is known as a “blood blister”) that typically clear up on their own.
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In the RAREST of instances – literally one in a million doses or more – recipients of vaccines can develop autoimmune diseases where the body is tricked into attacking itself – but this is very rare, can typically be treated medically, and RARELY if ever result in death.
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Almost 100% of people who are administered vaccines go on with their lives within minutes of receiving the injection, and are undoubtedly better off for having been inoculated as the rewards exponentially outweigh the risks.
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To give you an idea how safe most vaccines are, compared to the vaccine for COVID-19 – as we did in part one of this exclusive report – not one solitary soul has been proven to have died after receiving a stand-alone Measles (not to be confused with MMR) shot during the last 4 years. When one looks at the MMR vaccine, which contains Measles, Mumps and Rubella, VAERS reports that only 7 souls lost their lives as a result of receiving the vaccine.
“Between 2000-2015, the agency received 3175 US reports after MMR vaccine in adults. Of these, 168 (5%) were classified as serious, including 7 reports of death. Females accounted for 77% of reports. The most common signs and symptoms for all reports were pyrexia (19%), rash (17%), pain (13%), and arthralgia [ = joint pain] (13%).
We did not detect any new safety findings in empirical Bayesian data mining. We identified 131 reports of MMR vaccine administered to a pregnant woman; the majority of these vaccinations were in the first trimester and in 83 (62%), no AE was reported.”
So over a 15-year period only seven people were reported to have died as a result of receiving the MMR shot (in most cases due to RARE anaphylactic reaction to an adjuvant in the vaccine rather than to the vaccine itself), yet >500 people are dying WEEKLY from the COVID-19 vaccine.
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As also reported, with all FDA-approved vaccines (through COVID-19) the risk of anaphylaxis is less than two cases per million doses of vaccines administered to children, adolescents and healthy young adults.
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While anaphylaxis is serious and can be fatal in extreme cases, death and other complications can be prevented with rapid treatment using effective medications including epinephrine, corticosteroids and beta-agonists. These meds are on hand EVERYWHERE vaccines are administered.
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The same adjuvants – an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs – have been used for generations and their effects are KNOWN!
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This is NOT the case with the COVID-19 vaccine, yet I have met people with a healthy skepticism of vaccines who are considering being inoculated against COVID!
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I’ve even met people that are not up-to-date on their Tetanus shots. (Tetanus can have as high as 50% chance of mortality and kills between 50 and 250,000 unvaccinated people globally annually, depending on which report you read.) They are worried about their kids being vaccinated against the bacterial infection, something required before playing organized sports – yet there are few if any adverse reactions and deaths resulting from the vaccine.
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It truly beggars belief.
Brother John wrote,
“Why take a vaccine when the Establishment itself says you will still need to socially distance, wear a mask — and the lockdowns may continue???
Why take the vaccine when hydroxychloroquine works?!
Why take the vaccine when from every indication it is just the flu?!?!”
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And, again, this is for an illness that has between a 0.01% and 0.1% mortality rate for people who KNOW they have it.
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Shocking, to say the least.
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Still, this logic seems to have missed 50% of the American population who have either received the vaccine or plan on doing so!
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Anyone valuing their health should – you’d think – want to know precisely what they are sticking into their bloodstream before making such an important decision!
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Judgmental and hypocritical lefty scum, mask-commies, cretins fretting over chlorinated chicken (high concentrations of bleach/chlorine are already in city drinking water and pools), obsessive progressive weirdos ONLY eating organic, and the sort of fools forking out a fortune to shop at Wholefoods are typically both the first to ridicule people for eating McDonald’s because of how toxic it is for our bodies (true!), but are also the first in line, these holier-than-thou health nuts, to get inoculated with this untested Dr. Frankensteinesque concoction of a vaccine..
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I can’t think of a less pleasant set of people to concern myself over than this bunch, so that’ll be the last bit of energy I’ll expend on them…. 😉
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To be honest, I’d rather fork out 60 cents a day to buy some kid, languishing in a Congo jungle, a bottle of water than worry one sec about a snooty lefty dropping dead from a vaccine which IT (correct pronoun 😉 ) is demanding we ALL take.
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Rachel Levine with Penn. gov. Tom Wolf
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But back to the matter at hand….
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In part one of this series we talked about the immediate impact of the vaccine, which includes possible anaphylactic reactions due to the adjuvants used – adjuvants that have never EVER been used before in vaccines – as well as the short-term impact of the vaccine, demonstrated by the frightening death and injury rate released by VAERS.
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We also touched upon the active agent itself that acts like no other vaccine known to man due to the fact that it replicates its mRNA over and over and over again on a cellular level, instead of simply evoking an immune response and then being gobbled up by the body’s defense mechanisms.
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In a similar way that cancer does, I should add.
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This vaccine, if one looks at how it works in animals, is literally the murderous gift that keeps on giving, long after you no longer need or want it.
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Think of COVID like a pulmonary poison ivy, also known as Toxicodendron Radicans, that keeps spreading and spreading to every inch of your lungs until your body’s immune system clears it and sweeps up the mess it has left in its wake.
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With poison ivy you wait for your immune response to kick in and the body’s various types of white blood cells to do their job and remove it.
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The chemical in poison ivy, Urushiol, digs its way down through the epidermis, where it is metabolized by the body.
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Immune cells called T-lymphocytes (or T-cells) recognize the allergenic substance as a foreign antigen and go to work.
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They send out inflammatory signals called “cytokines,” which bring in white blood cells. Under specific instruction from the cytokines, these white blood cells turn into macrophages – the cellular bodies that gobble up antigens and the debris left behind.
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Macrophages are basically specialized Pacman-like cells (for those of you that recall the 1980’s Atari game) that gobble up infectious agents, damaged cells and other foreign bodies circulating in our bloodstream.
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The macrophages eat foreign substances, but in doing so they also damage normal tissue (via the inflammatory response), resulting in the skin redness and rash that occurs with poison ivy, for example.
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A secondary wave of specialized macrophages then show up, then clean up that debris and abate the inflammation generated by the first phase of immune response, stopping the invader and resultant damage dead in its tracks.
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Problem is when the COVID antigen is introduced via vaccine inoculation, it is never cleaned up properly, as the secondary macrophages, or M2 phagocytes, are either disabled or simply never arrive.
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Whether this is by design (this virus did perhaps originate from a lab in Wuhan, after all), or simply part of the illness or specifically the vaccine, no one quite knows for sure.
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So the inoculated antigen in the case of COVID, if it has been introduced to the body via a vaccination, will continue to wreak havoc on the body in the years to come when an immune response is needed to battle lung infection.
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There’s no doubt in my mind on that score.
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When you’re inoculated/infected with the coronavirus vaccine (it being an infection, whether or not it has been attenuated or not), the mRNA in the attenuated virus contains “instructions” for building what is referred to as a spike protein – one that has been identified on the surface of the SARS-CoV2 virus.
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Spike proteins work a bit like sticky lock picks which latch onto our cells prior to infection.
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This is how COVID-19 infects and invades our cells and also how the immune response battles back.
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COVID’s spike proteins can, in fact, morph into the necessary shape that interact with proteins on the surface of our human cells.
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The vaccine also targets these.
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The cell’s reverse transcriptase enzymes are called into action, leading to the mass production of the specific spike (S) protein.
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A 2019 a study out of the University of Hong Kong (“Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection” — www.insight.jci.org/articles/view/123158) demonstrated that the “Anti-spike IgG antibody in the vaccine caused severe acute lung injury by skewing macrophage response” and therefore interrupting the normal process that occurs with most people infected with COVID.
The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States.
So, instead of the virus being
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This results in an autoimmune condition where the vaccine-induced antibodies turn on us.
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Several years ago an investigation was undertaken to “study the effect vaccine-induced, spike-protein antibodies have on preventing SARS-CoV infections and to examine the possible effect the spike-protein antibodies have on the immune system versus how bodies react after organically beating back a COVID infection”.
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What the brave and brilliant Hong Kong researchers, led by esteemed virologist Li Liu, discovered was quite shocking.
“Sixteen macaque monkeys were given two injections; half of the animals received a modified vaccinia virus with an inserted spike protein (ADS-MVA) or a control vaccine made with a modified vaccinia virus without the spike protein antigen (ADC-MVA).
Three healthy, non-vaccinated monkeys were included as additional controls.
The animals were sacrificed between weeks 9 and 21, after receiving the second injection; the vaccine containing the spike protein induced very high antibody responses to the spike protein (anti-S-IgG).
Although the antibodies had reduced the viral load in the upper respiratory tract,
they caused a serious, antibody-enhanced injury in the lungs.
In fact, there was a direct and positive correlation between the level of antibody in serum and the degree of lung injury. The tissues had evidence of diffuse alveolar damage (DAD), with various degrees of exudate (pus-like fluid) and hemorrhage (bleeding).”
So, in layman’s terms, the better the immune response, the worse off you were!
This does not bode well for younger, healthier people – who typically generate a stronger immune response to vaccinations – who probably would not have even gotten sick if they’d been infected by COVID-19 they caught at a party or on public transportation.
Now, instead of their healthy immune systems producing both sets of macrophages — both the “cops” and the “garbage collectors” to pick up the mess — so as to rid their bodies of the infection, their defense mechanisms are going to falter.
And none of this is because of COVID, but due entirely to the vaccine!!
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And even more worryingly, the type of macrophages that typically gobble up debris and reduce inflammation (M2 phagocytes) – after the first set of M1 phagocytes departs or dies – were NOWHERE to be seen!!
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There are two primary types of macrophages:
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HOWEVER, after being inoculated by the COVID-19 vaccine, antibodies which were created by the body to fend off the attenuated SARS-CoV spike protein which was introduced by the vaccine (which spike protein appears specifically in people that were inoculated via the vaccine and NOT the actual illness) oddly also attach to the surface of circulating M2 (secondary) macrophages (the healing & cleanup crew) and weaken their function, allowing the M1 macrophages to release unchecked quantities of cytokines [image] to go unchecked, resulting in a terrifying inflammatory response that, in theory, has no end.
Instead of healing and repairing the infected lung tissues, the anti-S-IgG antibodies stifle the M2 cells which heal and clean up the damaged area and alleviate M1-caused inflammation. So with this bizarre vaccine, we see FAR more inflammation than you’d see in most cases of transmitted COVID-19 infection.
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The results are a veritable disaster.
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Here is a Summary of the report’s findings:
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“We present evidence of a detrimental role of the anti-S-IgG (anti-spike protein antibody) and acute lung injury during a SARS-CoV infection.
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Vaccine-induced, spike-specific antibodies resulted in severe acute lung injury in SARS-CoV infected Chinese macaques.
Anti-S-IgG antibody failed to prevent SARS-CoV lower respiratory tract infection (pneumonia) and amplified (increased) M1 macrophage infiltration and accumulation in the lungs.
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Anti-S-IgG causes severe acute lung injury (ALI) when the lungs become re-infected and/or re-exposed to coronaviruses by removing the inflammation-resolving work of the M2 macrophages.
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Animals who died of SARS-CoV infection had an accumulation of pro-inflammatory M1 macrophages and an absence of wound-healing M2 macrophages in their lungs.
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Histological examination [the lung tissue of the sacrificed animals] in 6 of the vaccinated macaques revealed acute diffuse alveolar damage (DAD) with various degrees of severity. Most of the macaques in the control group given the non-spike protein vaccine showed only minor to moderate lung inflammation. (Note: alveoli are the tiny air sacs in the lungs that oxygenate the blood.)
Without the presence of the anti-S-IgG antibodies, M2 macrophages began [doing their normal job of ] healing the lungs within two days of infection.”
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Although this particular study was quite recent (2019) it is but one of MANY reports and studies dating back to 2002, documenting how damaging COVID vaccine(s) are going to be once a person is vaccinated and then is re-exposed to circulating coronaviruses….
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Sherri Tenpenny. MD, whom we featured in part one of this story, recently said in an interview with a Nevada politician and COVID-truther, that this is not the only problem caused by the COVID-19 vaccines, stating that “most standard respiratory viruses cause infection by binding to specific receptors on the surface of the host’s cells. To block this attachment, antibodies formed from previous infections or by vaccines bind the circulating virus and neutralize it. This stops, or at least weakens, the progression to a full-blown infection….However, in some viruses, the antibodies formed against them bind only loosely to the viral surface proteins. Instead of stopping an infection, this mechanism promotes invasion into the cell, enhancing the infection instead of stopping it.”
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And this is not exactly a new finding. In a 2002 study “of mice, ferrets, hamsters, and Cynomolgus monkeys, using various coronavirus proteins and various adjuvants, researchers reported immunopathology in every animal that had been vaccinated and then re-exposed to a SARS-CoV virus.”
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In that study, instead of the vaccine protecting the animals from the SARS coronavirus “it actually triggered a hyper-inflammatory response and destroyed the mechanism mammals have in place to regulate it.”
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Remember illness like the flu and COVID don’t kill us. It is typically our body’s response to them that does. Things like inflammation, high fever etc.
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In conclusion, the researchers wrote that:
“This combined experience provides concern for trials with SARS-CoV vaccines in humans. Clinical trials with SARS coronavirus vaccines have been conducted and reported to induce antibody responses and to be ‘safe’.
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However, the evidence for safety is for a short period of observation.
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The concern arising from the present report is for an immunopathologic reaction occurring among vaccinated individuals on (re)exposure to infectious SARS-CoV, the basis for developing a vaccine for SARS.
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The SARS-CoV vaccines all induced antibody protection against infection with SARS-CoV. However, [viral] challenge of the mice given any of the vaccines led to the occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components. Extreme caution in proceeding to application of a SARS-CoV vaccines in humans is indicated.”
Yes, extreme caution is needed before “proceeding to application” of said vaccines to humans.
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And we have done the EXACT opposite.
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In conclusion, I’d like to list a few things Dr Tenpenny asked during her interview with former Nevada City Mayor, Reinette Senum, in her own words.
- Does the vaccine prevent the infection or only lessen a patient’s symptoms?
- Does it keep them from spreading the virus? If so, why do we still need to distance and wear a mask?
- How long will the antibody last? In other words, how long to we have to worry about viral re-exposure?
- What will the longterm be of the residual effect of the vaccine-induced spike proteins circulating in the vaccinated person’s bloodstream?
- What if you already have a co-morbidity such as an autoimmune disease?
- How well does the vaccine even protect the elderly, many of whom have received a flu vaccine? Will it perhaps even hurt them?
- What happens if a vaccinated person is reinfected? Will their bodies be more suscpetible to COVID than if they’d never been vaccinated as the studies show?
Sadly, anyone who DARES ask any of these same questions publicly may find themselves blocked, shamed, attacked, ostracized, cancelled, even imprisoned.
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And confined, yes confined!!
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There is already talk of what the monsters at the World Economic Forum based in Davos Switzerland, are referring to as “a universal need for some form of a vaccination passport.” Although migrants arriving by caravan from Honduras, Guatemala and Mexico won’t need one, make no mistake, you will.
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The passport will not only be used to track dissidents, but to make the lives of good people that value their ability to travel freely between white nations without having to suffer the pain and danger of being vaccinated, IMPOSSIBLE.
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One of our researchers, donors and most important supporters in Europe sent us a story detailing the elite’s (by way of the corrupt World Health Organization) plan for an “e-vaccination certificate.”
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Gayle Markovitz (WHAT ARE THE CHANCES!!) for the Davos Agenda, and via the World Economic Forum’s official website, www.we.forum.org, writes,
“With this in mind, the World Health Organization (WHO) is looking closely into the use of technology in the COVID-19 response, and how it can work with member states toward an e-vaccination certificate. Importantly, the framework will need to be harmonized, when it comes to standards and the use cases for the certificate, by a normative body like the WHO to ensure that it upholds ethical and equitable principles.
There are also separate initiatives among the private sector, such as the Vaccine Credentials Initiative, which are feeding into this work by offering authentication tools and solutions.”
There you have it, folks – the monstrous globalist goals of the political and corporate elite exposed for ALL to see….
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In conclusion, I will leave you with my advice moving forward.
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Stay strong and stand by your beliefs. If you don’t want to get vaccinated, DON’T! Stockpile the tools you need to keep you and your family safe during this challenging period in our people’s history. If you are fortunate enough to have money, withdraw much of your bank balances, hide the cash and, in case things go cashless, invest in valuable and useful small-sized items that can be sold and traded for food. Decrease distance between you and your closest, while you increase the distance that exists between you and the State. Invest in a good generator, get some storage tanks for gas and get moving on topping them up!
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Make sure you have 6-12 months of supplies at your house. Candles, flashlights, batteries etc. Then start thinking about the long haul and what you will need to live well, in case you’re restricted in any way. Think dozens of large bags of oats and fortified breakfast cereals, cases of tinned tomatoes and vegetables, several pounds of aged cheese for milk protein and flavor (think hard Italian Parmigiano-Reggiano cheese) that can be stored at room temperature for months, cured pork sausage (the French do great cured sausage that can be left for years) or American beef jerky, dozens of cartons of long lasting UHT milk, boxes of instant mash potatoes that can be quite tasty with just a bit of hot water, a splash of UHT milk, a chicken boullion cube, a few slices of cured sausage, a chunk of aged cheese and a few spoons of canned veggies added. Store fruits like apples that don’t need to be cooked. Buy wheat crackers, chips and pretzels instead of bread that spoils, if you are partial to grain. Store anything that does not need to be boiled to be prepared and eaten – things that you can eat with or without hot water if the electric’s been shut off and you can’t build a fire where you are. Food and water, more than having thousands of rounds of ammo, will be key to your ability to hold out. If you don’t have six months’ worth of food in your house, but have a satellite dish, two cars, 5000 rounds of tracer ammunition and a whole lot of things you enjoy playing with and you’re out in the country, you’re buying the wrong things.
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Also be sure to buy several 50 gallon BPA-free plastic tubs (sterilized and dried on the day you use it) and fill them with water – adding one teaspoon of bleach per every five gallons of water – which you can then drink long after it’s been stored. Liquid is always the key and there’s much you can do to prepare yourself for the long haul, even if you don’t have the space or the abilty to store tubs of water. Think bottled water for example. Also keep cases of long-lasting orange and apple juice rich in vitamins for when the water is no longer drinkable without boiling and to top up your vitamin intake when the good food runs out.
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I will be writing a full piece, entitled “Preparing for the forthcoming global winter” to accompany my manual on “How to prepare yourself for a home invasion” that will be published on www.johndengent.com, broaching this important topic at a later date. Not some extravagantly unrealistic, hipster-styled preppers handbook mind you, but like my piece on how to prepare your family for an attack on the home, a succinct article with real word solutions providing ideas on staying alive and living well when times get rough in the period ahead. Remember, the more prepared you are, the longer you will be able to hold out when they start demanding you get the vaccine.
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And again, as John asked earlier, with all the evidence that is being ignored, is being vaccinated to prevent an infection with a 99.9% survival rate, worth the risks associated with an untested and obviously dangerous vaccine?
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I think not.
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So be prepared.
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End article.
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Excerpts from the cited Hong Kong University Study.
Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection
Authors – Li Liu, Qiang Wei, Qingqing Lin, Jun Fang, Haibo Wang, Hauyee Kwok, Hangying Tang, Kenji Nishiura, Jie Peng, Zhiwu Tan, Tongjin Wu, Ka-Wai Cheung, Kwok-Hung Chan, Xavier Alvarez, Chuan Qin, Andrew Lackner, Stanley Perlman, Kwok-Yung Yuen, and Zhiwei Chen.
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Published February 21, 2019
Here, we present evidence of a detrimental role of anti–S-IgG in ALI during SARS-CoV infection. Respiratory CoVs infection poses a unique challenge to the immune system: not only must the virus be rapidly eliminated, but lung inflammation must also be controlled to prevent acute respiratory failure (33). In the present study, we show that, despite markedly reducing virus titers, anti–S-IgG caused lung injury during the early stages of infection by abrogating a wound-healing macrophage response and TGF-β production, while promoting proinflammatory cytokine IL-8 and MCP1 production and inflammatory macrophage accumulation. To our knowledge, our data demonstrate a previously unrecognized mechanism underlying virus-mediated ALI and suggest that modulation of the anti-S antibody response or blockage of Fcγ receptors during acute infection might be needed for effective treatment for respiratory CoV infection.
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Many studies have demonstrated the role of NAbs induced by the S glycoproteins in protecting viral replication in susceptible hosts, including mice, ferrets, hamsters, and macaques (24, 34, 35). However, the effect of S-specific immunity in protecting against pulmonary immunopathology has been controversial. In some cases, vaccination-induced immunity assists the viral clearance and protects mice or ferrets against lethal challenge (36–39), whereas in many other situations, multiple vaccine platforms appear to induce increased eosinophilic proinflammatory pulmonary response upon challenge (18, 23, 40). These differences may be explained, in part, by the characteristics of the vaccine being studied, the infectious dose, and the viral strain employed, as well as by the type or quality of immune response elicited. Recent studies suggest that CD8+ T cell response plays a crucial role in viral clearance and protection of mice against eosinophilic immunopathology and lethal SARS-CoV infection, whereas immunopathology predominantly reflects an inadequate vaccine-induced Th1 response (20–23).
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In fact, a protective effect against pulmonary immunopathology mediated by full length S protein–based vaccine in SARS-CoV–infected nonhuman primate models has not been described, to our knowledge. Although several vaccine candidates protected macaques against viral replication in the lungs, pulmonary immunopathology was not evaluated in these studies (24, 41, 42). By contrast, it was shown that SARS-CoV–specific immune memory induced by prior infection enhanced lung inflammation following homologous challenge in African green monkeys (17). Similarly, augmentation of disease by vaccination has also been described in studies of atypical measles and dengue hemorrhagic fever, as well as several respiratory diseases, including respiratory syncytial virus (RSV) and pandemic influenza (16, 43). In the study of RSV vaccine conducted in 1966 and 1967, 80% of RSV vaccinees needed hospitalization, whereas only 5% of RSV-infected children in the control vaccine group required admission, although the underlying mechanisms remain incompletely understood. Using Chinese rhesus macaques, we show that an ADS-MVA–based vaccine protected macaques against viral replication but significantly enhanced acute DAD at both 7 and 35 dpi compared with the control ADC-MVA group, suggesting that S-specific but not MVA-specific immunity promotes ALI (Figure 1). Until now, it remains unknown if SARS vaccine candidates with a focus on the receptor-binding domain (RBD) of S protein can avoid the induction of ALI in nonhuman primates. These vaccines have been shown to induce highly potent NAb responses and elicit long-term protective immunity in immunized small animals (38).
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SARS-CoV infection of Chinese macaques is often characterized by the rapid control of viral replication with mild lung lesions in most macaques (25). The mechanisms underlying why Chinese macaques do not often develop ALI, as observed in most SARS patients, are largely unknown. Our data suggest that these effects, in part, reflect the rapid control of viral replication in the lungs, which peaked between 24 and 48 hours after inoculation (hpi) and diminished within 7 days, thus creating an interval between lung inflammation and high titer antibody production in most macaques. Indeed, although SARS-CoV infection resulted in significant infiltration of macrophages in the lungs, the number of macrophages was rapidly reduced following virus clearance at 3 dpi (Figure 5). At 7 dpi, inflammation appeared to be mostly resolved (Figure 5). By contrast, control of virus replication is less efficient in SARS patients, and the peak in viral load coincides with the first appearance of an antibody response, approximately 10 days after the onset of symptoms (6).
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The low rate of ALI and interval between lung inflammation resolution and antibody production, however, makes Chinese macaques an ideal animal model for the present study. Using vaccination and passive immunization, we conditioned anti-S antibody titers in macaques during the early stage of infection when ALI was not typically observed. We found that prior administration of anti–S-IgG led to massive accumulation of monocytes/macrophages in the lungs within 2 dpi. This result is consistent with previous reports, in which mice given the SARS vaccine exhibited an immunopathologic lung reaction after the subsequent challenge with SARS-CoV (18, 19). Moreover, in SARS patients, clinical course and outcome are more favorable in children younger than 12 years of age compared with adolescents and adults (44), indicating that prior alternative CoV infection might play a role in driving enhanced pulmonary inflammation. A recent study reported that pathogenic immune complexes promoted lung injury during the 2009 H1N1 pandemic (16). It remains unknown whether immune complexes may also play a role in driving ALI during SARS-CoV infection.
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Detailed analyses of macrophage heterogeneity at different stages of infection and in lungs with severe injury or mild lesion revealed distinct roles for proinflammatory and wound-healing macrophages in SARS disease progression. We observed that the early transition of macrophage responses from proinflammatory to wound healing with increased TGF-β expression is associated with inflammation resolution and mild lung injury. By contrast, abrogated wound healing by S-IgG resulted in decreased TGF-β production and prolonged classical macrophage activation, and it promoted severe lung injury. Our findings are primarily based on imaging of formalin-fixed tissues of infected macaques, which may have technical limitations. A detailed flow cytometric analysis would be helpful to further characterize macrophage subpopulations in infected lungs. Unfortunately, we were not allowed to obtain any live cells, including macrophages, for analysis by flow cytometry outside the BSL-3 laboratory in China, which is in line with “WHO biosafety guidelines for handling of SARS specimens” (https://www.who.int/csr/sars/biosafety2003_04_25/en/). Having said this, TGF-β is mainly derived from wound-healing macrophages but not from classically activated macrophages. Therefore, by staining both TGF-β and CD206 (another biomarker of wound-healing macrophages), we believe that the finding of reduction of this type of macrophages in the S-IgG–treated lungs is convincing.
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Patients who received convalescent plasma from recovered SARS patients had shorter hospital stays and lower mortality rates without evident adverse effects (45–47). These results might reflect a different quality of antibodies in recovered patients from deceased patients during early infection. Indeed, we previously observed that deceased patients had significantly higher NAbs with a very low level of anti-N antibodies in serum during the early stage of infection (14). In contrast, recovered patients had more rapid anti-N antibody and slower NAb development (14). Consistently, serum from deceased patients — but not SARS survivors during early stages of infection — enhanced IL-6, IL-8, and MCP1 production by wound-healing macrophages (Figure 8). We previously identified epitopes in S protein that elicited NAbs and antibodies that enhanced SARS-CoV infection (48, 49). Further studies that will attempt to identify antibodies and epitopes that mediate prevention or enhancement of ALI might be needed for future vaccine design and immunotherapy
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Lastly, blockade of FcγRs reduced proinflammatory cytokine production, suggesting a potential role of FcγRs for the postulated reprogramming of alternatively activated macrophage. FcγRs are functionally divided into activating and inhibitory receptors. Activating FcγRs, such as FcγRI, FcγRIIA, and FcγRIII, triggers production of proinflammatory chemokines and cytokines through an immunoreceptor tyrosine–based activation motif (ITAM) in their intracytoplasmic domain and SRC family kinases and spleen tyrosine kinase (SYK), whereas the inhibitory FcγR, FcγRIIB, has an immunoreceptor tyrosine–based inhibition motif (ITIM) in its intracytoplasmic domain and counteracts the signals that are mediated by activating FcγRs. Based on literature and our experiments, human monocyte–derived wound-healing macrophages express higher levels of CD16 (FcγRIII) and CD32A (FcγRIIA) (50). Therefore, it is likely that S-IgG promoted proinflammatory cytokine production through FcγRI and/or FcγRIIA. S-IgG did not affect classically activated macrophage function in vitro. This difference can be possibly explained by the high baseline level of proinflammatory cytokines before infection and the downregulated expression of FcγR on classically activated MDM by SARS-CoV treatment.
A Summary of the Study’s Findings:
- We present evidence of a detrimental role of the anti-S-IgG (anti-spike protein antibody) and acute lung injury during a SARS-CoV infection.
- Vaccine-induced, spike-specific antibodies resulted in severe acute lung injury in SARS-CoV infected Chinese macaques
- Anti-S-IgG antibody failed to prevent SARS-CoV lower respiratory tract infection (pneumonia) and amplify (increase) M1 macrophage infiltration and accumulation in the lungs.
- Anti-S-IgG causes severe acute lung injury (ALI) when the lungs become re-infected and/or re-exposed to coronaviruses by removing the inflammation-resolving work of the M2 macrophages.
- Animals who died of SARS-CoV infection had an accumulation of pro-inflammatory M1 macrophages and an absence of wound-healing M2 macrophages in their lungs.
- Histological examination [the lung tissue of the sacrificed animals] in 6 of the vaccinated macaques revealed acute diffuse alveolar damage (DAD) with various degrees of severity. Most of the macaques in the control group given the non-spike protein vaccine showed only minor to moderate lung inflammation. (Note: alveoli are the tiny air sacs in the lungs that oxygenate the blood.)
- Without the presence of the anti-S-IgG antibodies, M2 macrophages began healing the lungs within two days of infection.
https://photos.app.goo.gl/%5B%5D
Thank you –It came from this source:
https://www.naturalnews.com/2021-03-05-34-cases-miscarriage-and-stillbirth-reported-after-experimental-vaccines.html
Another well-researched and informative article.
They certainly make you think about what we’re sold and told.
The article mentioned Vietnam and Agent Orange. US Admiral Elmo Zumwalt authorised the Mekong Delta area to be sprayed with Agent Orange . His son, Elmo Zumwalt, Jr. was on a patrol boat in said Mekong Delta. The boat used to sail through mists of this Agent Orange. His father had to watch him slowly die of cancer in a very short time when he returned to America. What seems a good idea can bite you in the arse.
Why are people skeptical about Covid and its vaccine?
In Britain we’ve had 1O,OOO gimmegrants arrive via dinghies, all illegally. They are housed, given free food, education and medical care.
Very few are sent back. The Royal Navy and coast guards intercept these illegal gimmegrants and tow them TO Britain!
During the first lockdown I was asked by a bus driver “Is your journey necessary?”
Yet you can still book a flight to Portugal for a holiday. Hunh?
The airlines plead poverty, yet thousands of people fly into Britain every day. They complain that they have to self-isolate for 14 days. Yet I’m not allowed to see my parents or attend a funeral!
Brits have to stay at home yet Romanian fruit pickers are flown in to pick the crops whilst we have millions of Brits wondering how they can pay the bills or put food on the table. And yet more gimmegrants and economic invaders invite themselves here. All helped via our MPs [Members of Parliament] and councillors and I’m asked if MY bus journey is necessary?
You won’t be able to travel unless you have a vaccine passport or have a tracking chip inserted into the fleshy part of your hand between your thumb and index finger. Gimmegrants in dinghies are, of course, exempt, if entering a country illegally.
Covid is a good excuse to chip all people. They will be told they need to be chipped to travel to Spain. Millions will want to be chipped for a passport to Benidorm. I’m going to miss lockdown. 😉
Benidorm, a tourist resort city on the southeastern Spanish coast
Thanks, Carl.
It is amazing how people can trust media and government when in every poll, in every Western country, people say they do not. They believe people they know to be liars.
Tony Blair may now be discredited and out of politics, but the peepul now trust a new set of liars!
I found this pic of a young Blair fascinating — note the diabolical look in his eyes:
Tony with a lovable old fellow, Jimmy Savile (and I guess no one had the slightest idea he molested hundreds of English kids for decades):
All that matters is a spiritual breakthrough where I get people to trust their own eyeballs again. The truth is right out there in front of us, clear as day.
Jesus said over and over, “let him who has ears hear and him who has eyes see.” People do not understand this saying to this day. Certainly His primitive jewish followers did not grasp what he was getting at. They wanted him to create a jewish kingdom, throw the Romans out, and lead a jew army to conquer the world! Then every jew would have 2,500 slaves. This is still the doctrine.
Our egoic minds are making us blind, especially with fright.
We are then immune — immune to reality. No dog is this way. A dog will trust his instincts and growl at a person who is obviously creepy and a threat to his master or mistress. I suspect animals can even see auras, or sense them. An earthling, however, will gush to meet some famous creep! Look at this white girl in my native Rhode Island, all ecstatic to meet the Magic Negro:
Tony Blair is a pseudonym, altered to cover up him being caught having gay sex with a man in a public toilet in London — hence the change of name .
Tha towld not surprise me.
Wiki claims this:
Anthony Charles Lynton Blair was born at Queen Mary Maternity Home in Edinburgh, Scotland,[1] on 6 May 1953.[2][3] He was the second son of Leo and Hazel (née Corscadden) Blair.[4] Leo Blair was the illegitimate son of two entertainers and was adopted as a baby by Glasgow shipyard worker James Blair and his wife, Mary.[5] Hazel Corscadden was the daughter of George Corscadden, a butcher and Orangeman who moved to Glasgow in 1916. In 1923, he returned to (and later died in) Ballyshannon, County Donegal. In Ballyshannon, Corscadden’s wife, Sarah Margaret (née Lipsett), gave birth above the family’s grocery shop to Blair’s mother, Hazel.[6][7]
***
I wonder who these two mysterious entertainers were? Jews?
https://www.renovatio21.com/video-shock-violenza-della-polizia-belga-in-casa-di-una-famiglia-accusata-di-non-rispettare-le-regole/
Il problema sono proprio questi Covidioti,non li sopporto più.
I first began to question vaccinations in general, decades ago. My daughter developed a nasty reaction to a DPT shot (ironically, the same one who now argues with me tooth and nail about vaccinations).
I began objecting to the plethora of different shots given simultaneously at medical offices. My question, “what if there is an adverse reaction to one of these shots, how would I know which vaccination caused it?” was always met with the same blank deer-in-the-headlights stare. How dare I question the medical gods.
A pro-Trump co-worker with whom I had numerous conversations with about the fake and phony plandemic, told me matter of factly that he was going to get the vaccination. How do you fix stupid? I was flabbergasted. I told him enjoy the kool-aid.
Thanks.
I had a great female supporter from Edmonton, Alberta, Canada, a wife and mother of several children. She told me how twice the school superintendent browbeat and bullied her until she let them vaxx her kids. Both times her kids had severe negative reactions and had to go to the hospital.
She said “My people were Germans, and Catholics, and we were raised to respect the rules and authority. But after both my kids got sick from vaccines they swore were safe, that is one part of my heritage I no longer follow. These people are just frigging liars.”
Safe and effective, goyim! Get your COVID-19 test today!
https://tapnewswire.com/2021/03/here-is-proof-the-covid-test-is-not-as-advertised-and-actually-swabs-the-cribriform-plate-woman-leaks-spinal-fluid-after-pcr-test-punctures-membrane
Thanks — used:
https://johndenugent.com/how-to-sell-a-dangerous-vaccine-no-one-wants-spineless-fools-caving-in-and-taking-it-traitors-pretending-to/